Higher-dose RT lowers risk of recurrence but does not improve survival for men with prostate cancer

High-dose radiotherapy did not improve survival for men with intermediate-risk prostate cancer but did improve biochemical control and rates of distant metastases, when compared to standard radiotherapy. Men who received higher-dose radiotherapy underwent fewer salvage therapies to control tumors that had grown larger or had spread to another body site; however, they also experienced more side effects than did men on the standard radiotherapy treatment arm.